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: Understanding innate immunity (physical barriers, phagocytosis) and adaptive immunity (B-cells, T-cells, and antibody structures).

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| Feature | Exotoxin | Endotoxin (LPS) | |---------|----------|-----------------| | Source | Gram+/Gram- bacteria | Gram-negative only | | Chemistry | Protein | Lipid A + polysaccharide | | Heat stability | Labile (except some) | Stable | | Toxicity | Very high (μg) | Low (mg) | | Effect | Specific (e.g., neurotoxin) | Fever, shock, DIC | | Example | Tetanospasmin, Cholera toxin | E. coli septic shock |

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: Enterobacteriaceae (E. coli, Salmonella), Pseudomonas , and respiratory pathogens ( Haemophilus , Bordetella ).

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: The first line of defense. It acts immediately and lacks memory. Components include skin barriers, phagocytic cells (macrophages, neutrophils), and the complement system. | Feature | Exotoxin | Endotoxin (LPS) |

Comparison matrices detailing different bacterial toxins, viral structures, or drug classes accelerate retention and serve as excellent study aids. How to Use These PowerPoint Notes for Maximum Retention

: Dimorphic fungi (e.g., Histoplasma capsulatum ) inhaled from the environment. They exist as molds at room temperature and yeasts at body temperature. Medical Parasitology